Design of selective Cathepsin inhibitors

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4622-5. doi: 10.1016/j.bmcl.2009.06.090. Epub 2009 Jun 27.

Abstract

A number of molecular recognition features have been exploited in structure-based design of selective Cathepsin inhibitors.

MeSH terms

  • Cathepsins / antagonists & inhibitors*
  • Cathepsins / metabolism
  • Computer Simulation
  • Crystallography, X-Ray
  • Drug Design
  • Protease Inhibitors / chemical synthesis
  • Protease Inhibitors / chemistry*
  • Protease Inhibitors / pharmacology
  • Structure-Activity Relationship

Substances

  • Protease Inhibitors
  • Cathepsins